Characterization of blaCTX-M-27/F1:A2:B20 Plasmids Harbored by Escherichia coli Sequence Type 131 Sublineage C1/ H 30R Isolates Spreading among Elderly Japanese in Nonacute-Care Settings

Antimicrob Agents Chemother. 2020 Apr 21;64(5):e00202-20. doi: 10.1128/AAC.00202-20. Print 2020 Apr 21.

Abstract

We characterized 29 blaCTX-M-27-harboring plasmids of Escherichia coli sequence type 131 (ST131) sublineage C1/H30R isolates from healthy individuals and long-term-care facility (LTCF) residents. Most (27/29) plasmids were of the FIA, FIB, and FII multireplicon type with the same plasmid multilocus sequence typing (pMLST). Several plasmids (7/23) from LTCF residents harbored only blaCTX-M-27 as the resistance gene; however, their fundamental structures were very similar to those of previously isolated blaCTX-M-27/F1:A2:B20 plasmids, suggesting their prevalence as a newly arising public health concern.

Keywords: F1:A2:B20 plasmid; blaCTX-M-27; elderly people; next-generation sequencing analysis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged, 80 and over
  • Anti-Bacterial Agents / pharmacology
  • Drug Resistance, Multiple, Bacterial / genetics
  • Escherichia coli / drug effects
  • Escherichia coli / genetics*
  • Escherichia coli / isolation & purification
  • Escherichia coli Infections / epidemiology*
  • Escherichia coli Infections / microbiology
  • Escherichia coli Proteins / genetics*
  • High-Throughput Nucleotide Sequencing
  • Humans
  • Japan / epidemiology
  • Long-Term Care
  • Microbial Sensitivity Tests
  • Multilocus Sequence Typing
  • Plasmids / classification
  • Plasmids / genetics*
  • Sequence Analysis, DNA
  • beta-Lactamases / genetics*

Substances

  • Anti-Bacterial Agents
  • Escherichia coli Proteins
  • CTX-M-27, E coli
  • beta-Lactamases