In vitro activity of isavuconazole against three species of Acanthamoeba

J Fr Ophtalmol. 2020 Apr;43(4):330-333. doi: 10.1016/j.jfo.2019.06.014. Epub 2020 Mar 6.

Abstract

Acanthamoeba keratitis due to a genus of free-living amoebae is a severe corneal infection. Treatment of this disease is based on the combined use of antiseptics and other drugs, including azoles. We tested isavuconazole, the latest marketed azole, in vitro, against A. castellanii, A. lenticulata and A. hatchetti. Our results show that isavuconazole presents slight amoebistatic activity against A. castellanii trophozoites but no cysticidal activity. Isavuconazole could be used only in association for management of AK due to A. castellanii.

Keywords: Acanthamoeba; Amibe libre; Free-living amoebae; Isavuconazole; Keratitis; Kératite.

MeSH terms

  • Acanthamoeba / classification
  • Acanthamoeba / drug effects*
  • Acanthamoeba / growth & development
  • Acanthamoeba / physiology
  • Acanthamoeba Keratitis / drug therapy
  • Acanthamoeba Keratitis / parasitology*
  • Acanthamoeba castellanii / drug effects
  • Acanthamoeba castellanii / growth & development
  • Acanthamoeba castellanii / physiology
  • Animals
  • Dose-Response Relationship, Drug
  • Humans
  • Nitriles / pharmacology*
  • Nitriles / therapeutic use
  • Parasite Encystment / drug effects
  • Parasitic Sensitivity Tests
  • Pyridines / pharmacology*
  • Pyridines / therapeutic use
  • Triazoles / pharmacology*
  • Triazoles / therapeutic use
  • Trophozoites / drug effects

Substances

  • Nitriles
  • Pyridines
  • Triazoles
  • isavuconazole