Correlation Between E6 and E7 Oncogenes and Malignant Transformation of Laryngeal Papillomatosis (LP) with Human Papillomavirus (HPV) in Pediatric Population

Fetal Pediatr Pathol. 2021 Aug;40(4):290-294. doi: 10.1080/15513815.2019.1707921. Epub 2020 Mar 9.

Abstract

Laryngeal papillomatosis (LP) is the most common benign neoplasm affecting the upper respiratory tract mucosa in children. The most common genotypes of HPV associated with LP are types 6 and 11. Methods: Among 187 patients identified in our institution with LP, four cases showed malignant transformation to invasive squamous carcinoma. Results: These patients had tumors with HPV viruses that showed high expression of oncogene E6 and E7 and low expression of E2. Conclusion: Malignant transformation of LP is associated with oncogenic expression of E6 and E7.

Keywords: E7; laryngeal papillomatosis; low-risk HPV; malignant transformation; oncogene E6; pediatrics.

MeSH terms

  • Alphapapillomavirus* / genetics
  • Child
  • Humans
  • Laryngeal Neoplasms
  • Oncogene Proteins, Viral* / genetics
  • Oncogenes / genetics
  • Papilloma
  • Papillomaviridae / genetics
  • Papillomavirus E7 Proteins / genetics
  • Papillomavirus Infections* / complications
  • Papillomavirus Infections* / genetics

Substances

  • Oncogene Proteins, Viral
  • Papillomavirus E7 Proteins

Supplementary concepts

  • Laryngeal papillomatosis