l-Cysteine decorated nanoscale metal-organic frameworks delivering valproic acid/cisplatin for drug-resistant lung cancer therapy

Chem Commun (Camb). 2020 Apr 7;56(27):3919-3922. doi: 10.1039/c9cc09712k. Epub 2020 Mar 9.

Abstract

We design multifunctional CDDP-VPA@ZrMOF-Cys-PEG nanoparticles (CVZP NPs) based on the properties of valproic acid (VPA) that can downregulate the expression of vascular endothelial growth factor (VEGF) to reduce the drug resistance of tumor cells. In vivo experiments confirm that chemotherapy combined with microwave thermal therapy (MWTT) can significantly improve the therapeutic effect of cisplatin-resistant lung cancer.

MeSH terms

  • Animals
  • Antineoplastic Agents / administration & dosage*
  • Antineoplastic Agents / chemistry
  • Cell Line
  • Cell Survival / drug effects
  • Cisplatin / administration & dosage*
  • Cisplatin / chemistry
  • Cysteine / administration & dosage*
  • Cysteine / chemistry
  • Drug Delivery Systems*
  • Drug Resistance, Neoplasm
  • Humans
  • Lung Neoplasms / drug therapy*
  • Lung Neoplasms / metabolism
  • Lung Neoplasms / pathology
  • Male
  • Metal-Organic Frameworks / administration & dosage*
  • Metal-Organic Frameworks / chemistry
  • Mice, Inbred BALB C
  • Mice, Inbred ICR
  • Mice, Nude
  • Nanoparticles / administration & dosage*
  • Nanoparticles / chemistry
  • Polyethylene Glycols / administration & dosage
  • Polyethylene Glycols / chemistry
  • Tumor Burden / drug effects
  • Valproic Acid / administration & dosage*
  • Valproic Acid / chemistry
  • Vascular Endothelial Growth Factor A / metabolism
  • Zirconium / administration & dosage*
  • Zirconium / chemistry

Substances

  • Antineoplastic Agents
  • Metal-Organic Frameworks
  • Vascular Endothelial Growth Factor A
  • vascular endothelial growth factor A, mouse
  • Polyethylene Glycols
  • Valproic Acid
  • Zirconium
  • Cysteine
  • Cisplatin