pH-Triggered Drug Release Controlled by Poly(Styrene Sulfonate) Growth Hollow Mesoporous Silica Nanoparticles

Fajar R Wibowo; Ozi A Saputra; Witri W Lestari; Mamoru Koketsu; Rino R Mukti; Ronny Martien

doi:10.1021/acsomega.9b04167

pH-Triggered Drug Release Controlled by Poly(Styrene Sulfonate) Growth Hollow Mesoporous Silica Nanoparticles

ACS Omega. 2020 Feb 20;5(8):4261-4269. doi: 10.1021/acsomega.9b04167. eCollection 2020 Mar 3.

Authors

Fajar R Wibowo¹, Ozi A Saputra², Witri W Lestari¹, Mamoru Koketsu³, Rino R Mukti⁴, Ronny Martien⁵

Affiliations

¹ Chemistry Department, Faculty of Mathematics and Natural Sciences, Universitas Sebelas Maret, Jl Ir. Sutami 36A, Surakarta 57126, Indonesia.
² Master Program of Chemistry, Graduate School of Universitas Sebelas Maret, Jl Ir. Sutami 36A, Surakarta 57126, Indonesia.
³ Department of Chemistry and Biomolecular Science, Faculty of Engineering, Gifu University, Gifu 501-1193, Japan.
⁴ Division of Inorganic and Physical Chemistry, Research Center for Nanosciences and Nanotechnology, Center for Catalysis and Reaction Engineering, Institut Teknologi Bandung, Jl. Ganesha No. 10 Bandung 40132, Indonesia.
⁵ Department of Pharmaceutics, Faculty of Pharmacy, Universitas Gadjah Mada, Sekip Utara, Yogyakarta 55281, Indonesia.

Abstract

In the current report, hollow mesoporous silica (HMS) nanoparticles were successfully prepared by means of a hard-templating method and further modified with poly(styrene sulfonate) (PSS) via radical polymerization. Structural analysis, surface spectroscopy, and thermogravimetric characterization confirmed a successful surface modification of HMS nanoparticles. A hairy PSS was clearly visualized by high-resolution transmission electron microscopy measurement, and it is grown on the surface of HMS nanoparticles. The Brunauer-Emmett-Teller surface area and average pore size of HMS nanoparticles were reduced after surface modification because of the pore-blocking effect, which indicated that the PSS lies on the surface of nanoparticles. Nevertheless, the PSS acts as a "nano-gate" to control the release of curcumin which is triggered by pH. The drug-release profile of unmodified HMS nanoparticles showed a stormed release in both pH 7.4 and 5.0 of phosphate buffer saline buffer solution. However, a slow release (9.92% of cumulative release) of curcumin was observed at pH 7.4 when the surface of HMS nanoparticles was modified by PSS. The kinetic release study showed that the curcumin release mechanism from PSS@HMS nanoparticles followed the Ritger-Peppas kinetic model, which is the non-Fickian diffusion. Therefore, the PSS-decorated HMS nanoparticles demonstrate potential for pH-triggered drug release transport.