Effects of quercetin on antioxidant potential in the experimental periodontitis development

Andrii Demkovych; Yurii Bondarenko; Petro Hasiuk

doi:10.1556/1646.11.2019.06

Effects of quercetin on antioxidant potential in the experimental periodontitis development

Interv Med Appl Sci. 2019 Mar;11(1):60-64. doi: 10.1556/1646.11.2019.06.

Authors

Andrii Demkovych¹, Yurii Bondarenko², Petro Hasiuk¹

Affiliations

¹ Department of Orthopedic Dentistry, I. Ya. Horbachevsky Ternopil State Medical University of the Public Health Ministry of Ukraine, Ternopil, Ukraine.
² Department of Pathophysiology, I. Ya. Horbachevsky Ternopil State Medical University of the Public Health Ministry of Ukraine, Ternopil, Ukraine.

Abstract

The results of experimental research of antioxidant system are presented in this article. Superoxide dismutase activity, catalase, and ceruloplasmin have been determined on the 7^th and 14^th days of experimental periodontitis development both without correction and with the injection of a water-soluble quercetin drug (corvitin). Hence, there was a decrease in superoxide dismutase activity, intensive increase in catalase activity, and ceruloplasmin maintenance in the blood serum during acute period of inflammatory process. The usage of flavonoid for 7 days resulted in stabilization of radical oxidation due to reduction of superoxide dismutase activity, maintenance at the high-level catalase activity, and ceruloplasmin concentration in the rat's blood plasma with experimental bacterial-immune periodontitis.

Keywords: antioxidant protection; catalase; ceruloplasmin; periodontitis; quercetin; superoxide dismutase.

Grants and funding

Funding sources: No financial support was received for this study.