Korean Red Ginseng attenuates type 2 diabetic cardiovascular dysfunction in Otsuka Long-Evans Tokushima Fatty rats

Mohammad Amjad Hossain; Dongbin Lee; Bumseok Kim; Chang-Won Kang; Nam Soo Kim; Jong-Hoon Kim

doi:10.1016/j.jgr.2018.12.003

Korean Red Ginseng attenuates type 2 diabetic cardiovascular dysfunction in Otsuka Long-Evans Tokushima Fatty rats

J Ginseng Res. 2020 Mar;44(2):308-311. doi: 10.1016/j.jgr.2018.12.003. Epub 2018 Dec 16.

Authors

Mohammad Amjad Hossain¹, Dongbin Lee², Bumseok Kim¹, Chang-Won Kang¹, Nam Soo Kim¹, Jong-Hoon Kim¹

Affiliations

¹ College of Veterinary Medicine, Biosafety Research Institute, Jeonbuk National University, Iksan, Republic of Korea.
² College of Veterinary Medicine, Western University of Health Sciences, Pomona, USA.

Abstract

Extracts of ginseng species show antihyperglycemic activity. We evaluated the inhibitory effects of diabetic complications for Korean Red Ginseng (KRG), which is enriched in ginsenosides using Otsuka Long-Evans Tokushima Fatty (OLETF) rats. The animals were divided into one of four groups (n = 6∼9): Long-Evans-Tokushima-Otsuka rats (control rats), OLETF rats, rats given 200 mg/kg KRG, and rats given 400 mg/kg KRG. We examined the protective potential of KRG against type 2 diabetic illnesses. The results exhibited that KRG showed significant antihyperglycemic and antioxidative effects in KRG-treated OLETF rats. And, our results proposed the amelioration of cardiac function through normalized ejection fraction, fractional shortening, and vascular reactivity. Furthermore, histopathological abnormalities in the OLETF rats were prevented by KRG treatment.

Keywords: Korean Red Ginseng; Protection; Type 2 diabetes; hemodynamics; vesicular function.