Abstract
The results of studies of a newly isolated Serratia species K-57 strain are presented. The strain is characterized by antiviral activity towards human influenza A/Aichi/2/68/H3N2, vaccinia, mouse smallpox, and herpes simplex-2 viruses. The detected characteristics of the strain, including the data on activities on nucleolytic enzymes, recommend it for the development of therapeutic and preventive antiviral drugs.
Keywords:
Serratia genus nucleases; human influenza A/H3N2 virus; mouse smallpox; vaccinia; herpes simplex-2 viruses.
MeSH terms
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Animals
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Antiviral Agents / isolation & purification
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Antiviral Agents / pharmacology*
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Bacterial Proteins / isolation & purification
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Bacterial Proteins / pharmacology*
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Chlorocebus aethiops
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Deoxyribonucleases / isolation & purification
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Deoxyribonucleases / pharmacology*
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Dogs
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Herpesvirus 2, Human / drug effects
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Herpesvirus 2, Human / growth & development
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Humans
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Influenza A Virus, H3N2 Subtype / drug effects
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Influenza A Virus, H3N2 Subtype / growth & development
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Madin Darby Canine Kidney Cells
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Mice
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Microbial Sensitivity Tests
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Ribonucleases / isolation & purification
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Ribonucleases / pharmacology*
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Serratia / chemistry*
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Vaccinia virus / drug effects
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Vaccinia virus / growth & development
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Variola virus / drug effects
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Variola virus / growth & development
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Vero Cells
Substances
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Antiviral Agents
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Bacterial Proteins
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Deoxyribonucleases
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Ribonucleases