Modulation of DNA and RNA by PNA

Penthip Muangkaew; Tirayut Vilaivan

doi:10.1016/j.bmcl.2020.127064

Modulation of DNA and RNA by PNA

Bioorg Med Chem Lett. 2020 May 1;30(9):127064. doi: 10.1016/j.bmcl.2020.127064. Epub 2020 Feb 27.

Authors

Penthip Muangkaew¹, Tirayut Vilaivan²

Affiliations

¹ Organic Synthesis Research Unit, Department of Chemistry, Faculty of Science, Chulalongkorn University, Phayathai Road, Patumwan, Bangkok 10330, Thailand.
² Organic Synthesis Research Unit, Department of Chemistry, Faculty of Science, Chulalongkorn University, Phayathai Road, Patumwan, Bangkok 10330, Thailand. Electronic address: vtirayut@chula.ac.th.

PMID: 32147357
DOI: 10.1016/j.bmcl.2020.127064

Abstract

Peptide nucleic acid (PNA), a synthetic DNA mimic that is devoid of the (deoxy)ribose-phosphate backbone yet still perfectly retains the ability to recognize natural nucleic acids in a sequence-specific fashion, can be employed as a tool to modulate gene expressions via several different mechanisms. The unique strength of PNA compared to other oligonucleotide analogs is its ability to bind to nucleic acid targets with secondary structures such as double-stranded and quadruplex DNA as well as RNA. This digest aims to introduce general readers to the advancement in the area of modulation of DNA/RNA functions by PNA, its current status and future research opportunities, with emphasis on recent progress in new targeting modes of structured DNA/RNA by PNA and PNA-mediated gene editing.

Keywords: Antigene; Antisense; Gene edit; Oligonucleotide therapeutics; Peptide nucleic acid.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

DNA / chemistry*
Gene Expression Regulation
Nucleic Acid Conformation
Peptide Nucleic Acids / chemistry*
RNA / chemistry*

Substances

Peptide Nucleic Acids
RNA
DNA