Designing novel biomaterials for tissue engineering purpose is an obvious necessary considering ever increasing need for appropriate biocompatibility and properties to achieve the maximum regeneration. In this research, a new type of biomaterial based on poly (phenylene sulfide) (PPS) and reduced graphene oxide (rGO) was synthesized and applied within chitosan based hydrogel to evaluate its performance as a wound dressing potentially. Fourier transform infrared spectroscopy (FTIR), X-ray diffraction spectrometry (XRD), scanning electron microscopy (SEM) and compression tests were performed to assess suitability of composite biomaterial. Thermal behavior of the PPS/rGO composite was evaluated by differential scanning calorimetry (DSC) and thermal gravimetric analysis (TGA). The PPS/rGO composition of 90: 10 (w/w) was selected because of having the highest biocompatibility and utilized in chitosan hydrogel. Chitosan hydrogel swelling ratio was declined from 800 to 200% by PPS/rGO addition; likewise, water vapor transition rate (WVTR) was dropped. A proper biocompatibility and cell attachment was confirmed, where porosity of ca. 80% appeared promising for tissue engineering uses. Overall, the result confirmed the appropriateness of PPS/rGO for tissue engineering uses.
Keywords: Agarose; Chitosan; Poly (phenylene sulfide); Reduced graphene oxide; Tissue engineering; Wound dressing.
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