Interventional Therapies in Acute Pulmonary Embolism

Robert Zhang; Taisei Kobayashi; Steven Pugliese; Sameer Khandhar; Jay Giri

doi:10.1016/j.iccl.2019.12.003

Interventional Therapies in Acute Pulmonary Embolism

Interv Cardiol Clin. 2020 Apr;9(2):229-241. doi: 10.1016/j.iccl.2019.12.003. Epub 2020 Feb 10.

Authors

Robert Zhang¹, Taisei Kobayashi¹, Steven Pugliese¹, Sameer Khandhar¹, Jay Giri²

Affiliations

¹ Hospital of the University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA.
² Hospital of the University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA. Electronic address: jay.giri@uphs.upenn.edu.

PMID: 32147123
DOI: 10.1016/j.iccl.2019.12.003

Abstract

Treatment of acute pulmonary embolism (PE) historically included anticoagulation and systemic thrombolytic therapy. More recently, catheter guided interventions provided promise of mitigating bleeding risks usually associated with systemic thrombolysis in intermediate to high risk PE patients. Catheter based interventions can broadly be divided into catheter directed thrombolysis and catheter based embolectomy. Both modalities are currently undergoing active research and each has their respective risks and benefits. The decision to administer these advanced therapies for acute PE can be challenging but can be accomplished via a multi-disciplinary PE response team.

Keywords: Bleeding; Cardiovascular mortality; Catheter-directed embolectomy; Catheter-directed thrombolysis; Pulmonary embolism; Tissue plasminogen activator.

Publication types

Review

MeSH terms

Acute Disease
Embolectomy / methods*
Fibrinolytic Agents / therapeutic use*
Humans
Pulmonary Embolism / therapy*
Risk Factors
Thrombolytic Therapy / methods*

Substances

Fibrinolytic Agents