Oxidative stress in alzheimer's disease: A review on emergent natural polyphenolic therapeutics

Luke Cassidy; Francesca Fernandez; Joel B Johnson; Mani Naiker; Akeem G Owoola; Daniel A Broszczak

doi:10.1016/j.ctim.2019.102294

Oxidative stress in alzheimer's disease: A review on emergent natural polyphenolic therapeutics

Complement Ther Med. 2020 Mar:49:102294. doi: 10.1016/j.ctim.2019.102294. Epub 2019 Dec 31.

Authors

Luke Cassidy¹, Francesca Fernandez², Joel B Johnson³, Mani Naiker⁴, Akeem G Owoola⁵, Daniel A Broszczak⁶

Affiliations

¹ School of Behavioural & Health Sciences, Faculty of Heath Sciences, Australian Catholic University, 1100 Nudgee Rd, Banyo, QLD, 4014, Australia.
² School of Behavioural & Health Sciences, Faculty of Heath Sciences, Australian Catholic University, 1100 Nudgee Rd, Banyo, QLD, 4014, Australia. Electronic address: Francesca.Fernandez@acu.edu.au.
³ School of Health, Medical and Applied Sciences, Central Queensland University, 630 Ibis Ave, North Rockhampton, QLD, 4701, Australia. Electronic address: joel.johnson@cqumail.com.
⁴ School of Health, Medical and Applied Sciences, Central Queensland University, 630 Ibis Ave, North Rockhampton, QLD, 4701, Australia. Electronic address: m.naiker@cqu.edu.au.
⁵ School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, 2 George St, Brisbane, 4000, QLD, Australia; Tissue Repair & Translational Physiology Program, Institute of Health & Biomedical Innovation, Queensland University of Technology, 60 Musk Ave, Kelvin Grove, Queensland, 4059, Australia. Electronic address: akeemgbolade.owoola@hdr.qut.edu.au.
⁶ School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, 2 George St, Brisbane, 4000, QLD, Australia; Tissue Repair & Translational Physiology Program, Institute of Health & Biomedical Innovation, Queensland University of Technology, 60 Musk Ave, Kelvin Grove, Queensland, 4059, Australia. Electronic address: daniel.broszczak@qut.edu.au.

PMID: 32147039
DOI: 10.1016/j.ctim.2019.102294

Abstract

Objectives: The aim of this research was to review the literature on Alzheimer's disease (AD) with a focus on polyphenolics as antioxidant therapeutics.

Design: This review included a search of the literature up to and including September 2019 in PubMed and MEDLINE databases using search terms that included: Alzheimer's Disease, Aβ peptide, tau, oxidative stress, redox, oxidation, therapeutic, antioxidant, natural therapy, polyphenol. Any review articles, case studies, research reports and articles in English were identified and subsequently interrogated. Citations within relevant articles were also examined for consideration in this review.

Results: Alzheimer's disease is a neurodegenerative disorder that is clinically characterised by the progressive deterioration of cognitive functions and drastic changes in behaviour and personality. Due to the significant presence of oxidative damage associated with abnormal Aβ accumulation and neurofibrillary tangle deposition in AD patients' brains, antioxidant drug therapy has been investigated as potential AD treatment. In particular, naturally occurring compounds, such as plant polyphenols, have been suggested to have potential neuroprotective effects against AD due to their diverse array of physiological actions, which includes potent antioxidant effects.

Conclusions: The impact of oxidative stress and various mechanisms of pathogenesis in AD pathophysiology was demonstrated along with the therapeutic potential of emergent antioxidant drugs to address such mechanism of oxidation.

Publication types

Review

MeSH terms

Alzheimer Disease / drug therapy*
Antioxidants / therapeutic use*
Humans
Oxidative Stress / drug effects*
Polyphenols / therapeutic use*

Substances

Antioxidants
Polyphenols