Sesquiterpenoids from the soft coral Lemnalia sp

Mingyu Liu; Pinglin Li; Xiangchao Luo; Leen van Ofwegen; Xuli Tang; Guoqiang Li

doi:10.1080/14786419.2020.1736062

Sesquiterpenoids from the soft coral Lemnalia sp

Nat Prod Res. 2021 Nov;35(21):3752-3756. doi: 10.1080/14786419.2020.1736062. Epub 2020 Mar 9.

Authors

Mingyu Liu^{1

2}, Pinglin Li^{1

2}, Xiangchao Luo^{1

2}, Leen van Ofwegen³, Xuli Tang⁴, Guoqiang Li^{1

2}

Affiliations

¹ Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, People's Republic of China.
² Laboratory of Marine Drugs and Biological Products, National Laboratory for Marine Science and Technology, Qingdao, People's Republic of China.
³ National Museum of Natural History, Leiden, the Netherlands.
⁴ College of Chemistry and Chemical Engineering, Ocean University of China, Qingdao, People's Republic of China.

PMID: 32146849
DOI: 10.1080/14786419.2020.1736062

Abstract

Two new neolemnane-type sesquiterpenoids lemnolins A (1) and B (2), together with one known tricyclic sesquiterpenoid (3) were isolated from the South China Sea soft coral Lemnalia sp. The structures were elucidated by comprehensive spectroscopic analysis and ECD analysis. Compound 1 displayed antiviral activity against influenza A (H1N1) virus in vitro.

Keywords: Lemnalia sp.; Soft coral; neolemnane-type sesquiterpenoids.

MeSH terms

Animals
Anthozoa*
China
Influenza A Virus, H1N1 Subtype*
Molecular Structure
Sesquiterpenes* / pharmacology

Substances

Sesquiterpenes