[Characterisation of the protective role of erythropoetin in a murine model of acute lung injury]

Abstract

In addition to its role in erythropoiesis, erythropoietin (Epo) plays a role in tissue protection, which includes cardioprotective, nephroprotective and neuroprotective effects. The presence of Epo and its receptor (Epo-R) in pulmonary tissue also suggests a cytoprotective effect of Epo in the lung. Our project aims to document this role in a murine model under-expressing Epo. The obtained results will lead to a better understanding of the cytoprotective effects of Epo and will also give an appreciation of its beneficial effects in cases of lung injury.

Keywords: Agressions pulmonaire; Cytoprotection; Erythropoietin; Erythropoïétine; Lung injury.