Pharmacogenomics for the efficacy of platinum-based chemotherapy: Old drugs, new integrated perspective

Chen-Xue Mao; Min Li; Wei Zhang; Hong-Hao Zhou; Ji-Ye Yin; Zhao-Qian Liu

doi:10.1016/j.biopha.2020.110057

Pharmacogenomics for the efficacy of platinum-based chemotherapy: Old drugs, new integrated perspective

Biomed Pharmacother. 2020 Jun:126:110057. doi: 10.1016/j.biopha.2020.110057. Epub 2020 Mar 4.

Authors

Chen-Xue Mao¹, Min Li², Wei Zhang³, Hong-Hao Zhou³, Ji-Ye Yin⁴, Zhao-Qian Liu⁵

Affiliations

¹ Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, PR China; Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha 410078, PR China; Engineering Research Center of Applied Technology of Pharmacogenomics, Ministry of Education, Changsha 410078, PR China.
² Department of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha 410008, PR China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, PR China.
³ Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, PR China; Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha 410078, PR China; Engineering Research Center of Applied Technology of Pharmacogenomics, Ministry of Education, Changsha 410078, PR China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, PR China.
⁴ Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, PR China; Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha 410078, PR China; Engineering Research Center of Applied Technology of Pharmacogenomics, Ministry of Education, Changsha 410078, PR China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, PR China. Electronic address: yinjiye@csu.edu.cn.
⁵ Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, PR China; Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha 410078, PR China; Engineering Research Center of Applied Technology of Pharmacogenomics, Ministry of Education, Changsha 410078, PR China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, PR China. Electronic address: zqliu@csu.edu.cn.

PMID: 32145590
DOI: 10.1016/j.biopha.2020.110057

Abstract

Platinum-based chemotherapy remains the cornerstone of treatment for many malignancies. However, although therapeutic efficiency varies greatly among individuals, there is a lack of pharmacogenomic biomarkers that can be used in clinical settings to identify chemosensitive patients and allow stratification. With the development of high-throughput screening techniques and systems biology approaches, a growing body of evidence has shown that platinum resistance is a multifactorial, multi-dimensional, dynamic process incorporating genetic background, tumor evolution and gut microbes. This review critically summarizes potential pharmacogenomic biomarkers for predicting the efficacy of platinum drugs and provides a comprehensive, time-varying perspective that integrates multiple markers.

Keywords: Biomarker; Efficacy; Pharmacogenomics; Platinum; Resistance.

Publication types

Review

MeSH terms

Antineoplastic Combined Chemotherapy Protocols / pharmacokinetics
Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
Biomarkers, Tumor / genetics*
Carboplatin / pharmacokinetics
Carboplatin / therapeutic use*
Cisplatin / pharmacokinetics
Cisplatin / therapeutic use*
DNA Repair / drug effects
DNA Repair / genetics
Genome-Wide Association Study
Humans
Pharmacogenetics / methods*
Pharmacogenomic Variants*

Substances

Biomarkers, Tumor
Carboplatin
Cisplatin