Hyperacmosins E-G, three new homoadamantane-type polyprenylated acylphloroglucinols from Hypericum acmosepalum

Fitoterapia. 2020 Apr:142:104535. doi: 10.1016/j.fitote.2020.104535. Epub 2020 Mar 5.

Abstract

Three new homoadamantane-type polyprenylated acylphloroglucinols, hyperacmosins E-G (1-3), with seven known compounds were isolated from the air-dried aerial parts of Hypericum asmosepalum. Their structures were determined by NMR, HRESIMS and experimental electronic circular dichroism (ECD) spectra. The hepatoprotective activity of these compounds were evaluated. Compounds 4 and 8 exhibited hepatoprotective activity against paracetamol-induced HepG2 cell damage.

Keywords: Hepatoprotective; Homoadamantane-type; Hypericum acmosepalum; PPAPs.

MeSH terms

  • Adamantane / analogs & derivatives
  • Adamantane / isolation & purification
  • Hep G2 Cells
  • Humans
  • Hypericum / chemistry*
  • Phloroglucinol / analogs & derivatives*
  • Polycyclic Compounds / chemistry
  • Polycyclic Compounds / isolation & purification*
  • Protective Agents / isolation & purification

Substances

  • Polycyclic Compounds
  • Protective Agents
  • sampsonione J
  • Phloroglucinol
  • Adamantane