Abstract
Total synthesis of isatindigotindoline C, a 3,3'-spiropyrrolidine oxindole alkaloid, is achieved in two steps using an exo-selective decarboxylative 1,3-dipolar cycloaddition as the key step. The synthesis verifies the originally assigned relative anti-stereochemistry for the bis-oxindole core of isatindigotindoline C.
Publication types
-
Research Support, N.I.H., Extramural
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
-
Cycloaddition Reaction / methods
-
Decarboxylation
-
Indole Alkaloids / chemical synthesis*
-
Oxindoles
-
Spiro Compounds / chemical synthesis
Substances
-
Indole Alkaloids
-
Oxindoles
-
Spiro Compounds
-
2-oxindole