Allergic and photoallergic contact dermatitis to chlorpromazine

Australas J Dermatol. 2020 Aug;61(3):e351-e353. doi: 10.1111/ajd.13254. Epub 2020 Mar 5.

Abstract

Chlorpromazine is known to produce both systemic phototoxic and photoallergic reactions. However, it may also cause photoallergic contact dermatitis and, albeit exceptionally, allergic contact dermatitis (ACD). We present a series of photoallergic contact dermatitis and ACD to chlorpromazine diagnosed at a tertiary centre cutaneous allergy unit between 1980 and 2019.

Keywords: allergic contact dermatitis; chlorpromazine; photoallergic contact dermatitis.

MeSH terms

  • Adult
  • Antipsychotic Agents / adverse effects*
  • Cheilitis / chemically induced
  • Chlorpromazine / adverse effects*
  • Dermatitis, Photoallergic / etiology*
  • Eyelids
  • Facial Dermatoses / chemically induced
  • Female
  • Fingers
  • Hand Dermatoses / chemically induced
  • Humans
  • Middle Aged
  • Patch Tests
  • Retrospective Studies

Substances

  • Antipsychotic Agents
  • Chlorpromazine