Clonocoprogens A, B and C, new antimalarial coprogens from the Okinawan fungus Clonostachys compactiuscula FKR-0021

Takahito Ouchi; Yoshihiro Watanabe; Kenichi Nonaka; Reiko Muramatsu; Chikako Noguchi; Miho Tozawa; Rei Hokari; Aki Ishiyama; Rima Koike; Hidehito Matsui; Yukihiro Asami; Yuki Inahashi; Takahiro Ishii; Toshiaki Teruya; Masato Iwatsuki; Hideaki Hanaki; Satoshi Ōmura

doi:10.1038/s41429-020-0292-7

Clonocoprogens A, B and C, new antimalarial coprogens from the Okinawan fungus Clonostachys compactiuscula FKR-0021

J Antibiot (Tokyo). 2020 Jun;73(6):365-371. doi: 10.1038/s41429-020-0292-7. Epub 2020 Mar 6.

Authors

Takahito Ouchi^#¹, Yoshihiro Watanabe^#², Kenichi Nonaka^{1

2}, Reiko Muramatsu², Chikako Noguchi², Miho Tozawa², Rei Hokari², Aki Ishiyama^{1

2}, Rima Koike³, Hidehito Matsui², Yukihiro Asami^{1

2}, Yuki Inahashi^{1

2}, Takahiro Ishii⁴, Toshiaki Teruya⁵, Masato Iwatsuki^{6

7}, Hideaki Hanaki², Satoshi Ōmura²

Affiliations

¹ Graduate School of Infection Control Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan.
² Kitasato Institute for Life Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan.
³ Graduate School of Science, Kitasato University, 1-15-1, Kitazato, Minami, Sagamihara, Kanagawa, 252-0373, Japan.
⁴ Faculty of Agriculture, University of the Ryukyus, Senbaru 1, Nishihara, Okinawa, 903-0213, Japan.
⁵ Faculty of Education, University of the Ryukyus, 1 Senbaru, Nishihara, Okinawa, 903-0213, Japan.
⁶ Graduate School of Infection Control Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan. iwatuki@lisci.kitasato-u.ac.jp.
⁷ Kitasato Institute for Life Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan. iwatuki@lisci.kitasato-u.ac.jp.

^# Contributed equally.

PMID: 32139881
DOI: 10.1038/s41429-020-0292-7

Abstract

Three new antimalarial compounds, clonocoprogens A, B, and C, were isolated from the static culture of an Okinawan fungus, Clonostachys compactiuscula FKR-0021. These compounds were new analogs of N¹⁴-palmitoylcoprogen, reported as a siderophore. They showed moderate antimalarial activity against chloroquine-sensitive and chloroquine-resistant Plasmodium falciparum strains, with IC₅₀ values ranging from 1.7 to 9.9 µM.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antimalarials / administration & dosage
Antimalarials / isolation & purification
Antimalarials / pharmacology*
Chloroquine / pharmacology
Drug Resistance
Hydroxamic Acids / administration & dosage
Hydroxamic Acids / isolation & purification
Hydroxamic Acids / pharmacology*
Hypocreales / metabolism*
Inhibitory Concentration 50
Japan
Plasmodium falciparum / drug effects*

Substances

Antimalarials
Hydroxamic Acids
Chloroquine
coprogen