Water-soluble fluorescent sensor for Zn2+ with high selectivity and sensitivity imaging in living cells

Bioorg Med Chem Lett. 2020 Apr 15;30(8):127073. doi: 10.1016/j.bmcl.2020.127073. Epub 2020 Feb 29.

Abstract

A new water-soluble 4-amino-1, 8-naphthalimide based fluorescent sensor, with iminoacetic acid and iminoethoxyacetic acid as receptor contained two different arms, was developed. Under physiological pH conditions, it demonstrates good water solubility, high selectivity and sensitivity for sensing Zn2+ with about 20-fold enhancement in aqueous solution, with a characteristic emission band of 4-amino-1, 8-naphthalimide with a green color centered at 550 nm. It was applied successfully to detect Zn2+ in living cells.

Keywords: Fluorescent sensor; Naphthalimide; PET; Water-soluble; Zinc.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Density Functional Theory
  • Dose-Response Relationship, Drug
  • Drug Discovery*
  • Fluorescent Dyes / chemical synthesis
  • Fluorescent Dyes / chemistry*
  • HeLa Cells
  • Humans
  • Molecular Structure
  • Optical Imaging
  • Solubility
  • Spectrometry, Fluorescence
  • Structure-Activity Relationship
  • Water / chemistry
  • Zinc / analysis*

Substances

  • Fluorescent Dyes
  • Water
  • Zinc