Biological function of protein tyrosine phosphatase H-type receptor and its progress in tumor

Zhengxi He; Jun Su; Qing Liu; Zihua Chen; Liangfang Shen; Haoyu Li

doi:10.11817/j.issn.1672-7347.2020.180612

Biological function of protein tyrosine phosphatase H-type receptor and its progress in tumor

Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2020 Jan 28;45(1):61-67. doi: 10.11817/j.issn.1672-7347.2020.180612.

[Article in English, Chinese]

Authors

Zhengxi He¹, Jun Su², Qing Liu², Zihua Chen³, Liangfang Shen¹, Haoyu Li²

Affiliations

¹ Department of Oncology, Xiangya Hospital, Central South University, Changsha 410008, China.
² Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha 410008, China.
³ Department of General Surgery, Xiangya Hospital, Central South University, Changsha 410008, China.

PMID: 32132299
DOI: 10.11817/j.issn.1672-7347.2020.180612

Abstract
in English, Chinese

Protein tyrosine phosphatase H-type receptor (PTPRH) gene encodes a gastric cancer associated protein, which exerts its biological function through tyrosine phosphorylation in the post-translational COOH- terminal region. PTPRH is abnormally expressed in a variety of tumors, and its biological function is closely related to the occurrence, development and prognosis of tumors.

蛋白酪氨酸磷酸酶H型受体(protein tyrosine phosphatase H receptor，PTPRH)基因是一种编码胃癌相关蛋白的基因，通过翻译后COOH-末端区域的酪氨酸磷酸化修饰发挥其生物学功能。PTPRH在多种肿瘤中呈异常表达，其生物学功能与肿瘤的发生、发展及预后密切相关。.

Keywords: biological function; protein tyrosine phosphatase H-type receptor; tumor.

MeSH terms

Humans
Phosphorylation
Protein Tyrosine Phosphatases
Proteins
Stomach Neoplasms*
Tyrosine

Substances

Proteins
Tyrosine
Protein Tyrosine Phosphatases

Abstract in English, Chinese

MeSH terms

Substances

Abstract
in English, Chinese