On biological availability dependent bone remodeling

Comput Methods Biomech Biomed Engin. 2020 Jun;23(8):432-444. doi: 10.1080/10255842.2020.1736050. Epub 2020 Mar 4.

Abstract

Modeling the evolution of bone density is relevant for understanding, simulation and possible prediction of bone response to external and internal influences. In this work we present a formulation for the bone density evolution process that takes into account not only the commonly considered mechanical stimulus, but, as novelty, also the influence of the availability of nutrients and hormones, with its implementation pursued within the finite element method. A simple uni-axial extension test is used to illustrate and compare our novel model against the classical approach. The results of the proposed modified model are promising for application to real-life problems.

Keywords: Bone remodeling; biological availability; density change; finite element method; growth.

MeSH terms

  • Biological Availability
  • Biomechanical Phenomena
  • Bone Density / physiology
  • Bone Remodeling / physiology*
  • Computer Simulation
  • Femur / physiology
  • Finite Element Analysis
  • Humans
  • Humerus / physiology
  • Models, Biological
  • Numerical Analysis, Computer-Assisted
  • Stress, Mechanical
  • Weight-Bearing