Abstract
The epidermal growth factor receptor (EGFR) belongs to the ERBB family of tyrosine kinase receptors. EGFR signaling cascade is a key regulator in cell proliferation, differentiation, division, survival, and cancer development. In this review, the EGFR structure and its mutations, signaling pathway, ligand binding and EGFR dimerization, EGF/EGFR interaction, and the progress in the development of EGFR inhibitors have been explored.
Keywords:
EGF; EGFR; ERBB-1; HER-1; Inhibitors; TGF-α; Tyrosine kinase; cancer; mAbs..
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MeSH terms
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Animals
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Antineoplastic Agents / chemistry*
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Antineoplastic Agents / pharmacology
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Antineoplastic Agents, Immunological / chemistry
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Antineoplastic Agents, Immunological / pharmacology
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Apoptosis / drug effects
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Cytokines / metabolism
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Drug Screening Assays, Antitumor
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ErbB Receptors / antagonists & inhibitors
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ErbB Receptors / genetics
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ErbB Receptors / metabolism
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Humans
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Ligands
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Models, Molecular
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Mutation
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Protein Binding
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Protein Conformation
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Protein Kinase Inhibitors / chemistry*
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Protein Kinase Inhibitors / pharmacology
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Signal Transduction
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Structure-Activity Relationship
Substances
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Antineoplastic Agents
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Antineoplastic Agents, Immunological
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Cytokines
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Ligands
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Protein Kinase Inhibitors
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EGFR protein, human
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ErbB Receptors