Gut bacteria Akkermansia elicit a specific IgG response in CSF of patients with MS

Amélie Vallino; Amélie Dos Santos; Camille V Mathé; Alexandra Garcia; Jérémy Morille; Emilie Dugast; Sita P Shah; Geneviève Héry-Arnaud; Charles-Antoine Guilloux; Patrick J Gleeson; Renato C Monteiro; Jean-Paul Soulillou; Jean Harb; Edith Bigot-Corbel; Laure Michel; Sandrine Wiertlewski; Arnaud B Nicot; David-Axel Laplaud; Laureline Berthelot

doi:10.1212/NXI.0000000000000688

Gut bacteria Akkermansia elicit a specific IgG response in CSF of patients with MS

Neurol Neuroimmunol Neuroinflamm. 2020 Mar 2;7(3):e688. doi: 10.1212/NXI.0000000000000688. Print 2020 May.

Authors

Amélie Vallino¹, Amélie Dos Santos¹, Camille V Mathé¹, Alexandra Garcia¹, Jérémy Morille¹, Emilie Dugast¹, Sita P Shah¹, Geneviève Héry-Arnaud¹, Charles-Antoine Guilloux¹, Patrick J Gleeson¹, Renato C Monteiro¹, Jean-Paul Soulillou¹, Jean Harb¹, Edith Bigot-Corbel¹, Laure Michel¹, Sandrine Wiertlewski¹, Arnaud B Nicot¹, David-Axel Laplaud¹, Laureline Berthelot²

Affiliations

¹ From the Centre de Recherche en Transplantation et Immunologie UMR1064 (A.V., A.D.S., C.V.M., A.G., J.M., E.D., S.P.S., J.-P.S., J.H., L.M., S.W., A.B.N., D.A.L., L.B.), INSERM, Université de Nantes; Univ Brest (G.H.-A., C.-A.G.), Inserm, EFS, UMR 1078, GGB; Unité de Bactériologie (G.H.-A.), Pôle de Biologie-Pathologie, Centre Hospitalier Régional et Universitaire de Brest, Hôpital de la Cavale Blanche, Boulevard Tanguy Prigent, Brest; Centre de Recherche sur l'Inflammation UMRS1149 (P.J.G., R.C.M.), INSERM, Université Paris Diderot, CNRS ERL8252; Department of biochemistry (J.H., E.B.-C.), CHU Nantes; Department of Neurology (L.M., S.W., D.-A.L.), CHU Nantes; and CIC 1214 (A.G., L.M., S.W., D.-A.L.), CHU Nantes, France.
² From the Centre de Recherche en Transplantation et Immunologie UMR1064 (A.V., A.D.S., C.V.M., A.G., J.M., E.D., S.P.S., J.-P.S., J.H., L.M., S.W., A.B.N., D.A.L., L.B.), INSERM, Université de Nantes; Univ Brest (G.H.-A., C.-A.G.), Inserm, EFS, UMR 1078, GGB; Unité de Bactériologie (G.H.-A.), Pôle de Biologie-Pathologie, Centre Hospitalier Régional et Universitaire de Brest, Hôpital de la Cavale Blanche, Boulevard Tanguy Prigent, Brest; Centre de Recherche sur l'Inflammation UMRS1149 (P.J.G., R.C.M.), INSERM, Université Paris Diderot, CNRS ERL8252; Department of biochemistry (J.H., E.B.-C.), CHU Nantes; Department of Neurology (L.M., S.W., D.-A.L.), CHU Nantes; and CIC 1214 (A.G., L.M., S.W., D.-A.L.), CHU Nantes, France. laureline.berthelot@inserm.fr.

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Akkermansia / immunology*
Antibodies, Bacterial / cerebrospinal fluid*
Gastrointestinal Microbiome*
Humans
Immunoglobulin G / cerebrospinal fluid
Multiple Sclerosis, Relapsing-Remitting* / cerebrospinal fluid
Multiple Sclerosis, Relapsing-Remitting* / immunology
Multiple Sclerosis, Relapsing-Remitting* / microbiology

Substances

Antibodies, Bacterial
Immunoglobulin G