Lobular Breast Carcinoma

Excerpt

Invasive lobular carcinoma is the second most common histologic form of breast cancer, representing 5% to 15% of all invasive breast cancers. It is composed of non-cohesive cells individually dispersed or organized in a single-file linear pattern in a fibrous stroma. Invasive lobular carcinoma is usually associated with lobular carcinoma in situ. It is now recognized as a biologically distinct disease from the more common invasive ductal carcinoma, with unique molecular pathogenesis and consequential implications on diagnosis and treatment. An understanding of these differences is crucial to tailor management strategies.