Electrophilically Activated Nitroalkanes in Reactions With Carbon Based Nucleophiles

Nicolai A Aksenov; Alexander V Aksenov; Sergei N Ovcharov; Dmitrii A Aksenov; Michael Rubin

doi:10.3389/fchem.2020.00077

Electrophilically Activated Nitroalkanes in Reactions With Carbon Based Nucleophiles

Front Chem. 2020 Feb 11:8:77. doi: 10.3389/fchem.2020.00077. eCollection 2020.

Authors

Nicolai A Aksenov¹, Alexander V Aksenov¹, Sergei N Ovcharov¹, Dmitrii A Aksenov¹, Michael Rubin^{1

2}

Affiliations

¹ Department of Chemistry, North Caucasus Federal University, Stavropol, Russia.
² Department of Chemistry, University of Kansas, Lawrence, KS, United States.

Abstract

Unusual reactivity of nitroalkanes, involving formation of aci-forms (nitronic acids or nitronates) and their subsequent interaction with carbon-based nucleophiles, is surveyed in this review.

Keywords: C-H functionalization; electrophilic attack; nitroalkanes; oximes; synthetic methodology.

Publication types

Review