Chemoenzymatic Halocyclization of 4-Pentenoic Acid at Preparative Scale

Georg T Höfler; Andrada But; Sabry H H Younes; Ron Wever; Caroline E Paul; Isabel W C E Arends; Frank Hollmann

doi:10.1021/acssuschemeng.9b07494

Chemoenzymatic Halocyclization of 4-Pentenoic Acid at Preparative Scale

ACS Sustain Chem Eng. 2020 Feb 24;8(7):2602-2607. doi: 10.1021/acssuschemeng.9b07494. Epub 2020 Jan 31.

Authors

Georg T Höfler¹, Andrada But¹, Sabry H H Younes^{1

2}, Ron Wever³, Caroline E Paul¹, Isabel W C E Arends⁴, Frank Hollmann¹

Affiliations

¹ Department of Biotechnology, Delft University of Technology, Van der Maasweg 9, 2629 HZ Delft, The Netherlands.
² Department of Chemistry, Faculty of Sciences, Sohag University, 82524 Sohag, Egypt.
³ Van't Hoff Institute for Molecular Sciences, University of Amsterdam, 1090 GD Amsterdam, The Netherlands.
⁴ Faculty of Science, University of Utrecht, Budapestlaan 6, 3584 CD Utrecht, The Netherlands.

Abstract

The scale-up of chemoenzymatic bromolactonization to 100 g scale is presented, together with an identification of current limitations. The preparative-scale reaction also allowed for meaningful mass balances identifying current bottlenecks of the chemoenzymatic reaction.