Cold Atmospheric Plasma as a Novel Therapeutic Tool for the Treatment of Brain Cancer

Manish Adhikari; Bhawana Adhikari; Anupriya Adhikari; Dayun Yan; Vikas Soni; Jonathan Sherman; Michael Keidar

doi:10.2174/1381612826666200302105715

Cold Atmospheric Plasma as a Novel Therapeutic Tool for the Treatment of Brain Cancer

Curr Pharm Des. 2020;26(19):2195-2206. doi: 10.2174/1381612826666200302105715.

Authors

Manish Adhikari¹, Bhawana Adhikari², Anupriya Adhikari³, Dayun Yan¹, Vikas Soni¹, Jonathan Sherman⁴, Michael Keidar¹

Affiliations

¹ Department of Mechanical and Aerospace Engineering, The George Washington University, Science & Engineering Hall, 800 22nd Street, NW, Washington, DC, 20052, United States.
² Plasma Bioscience Research Center, Applied Plasma Medicine Center, Department of Electrical and Biological Physics, Kwangwoon University, Seoul, 01897, Korea.
³ Department of Chemistry, Babasaheb Bhimrao Ambedkar University, Lucknow, 226025, India.
⁴ Neurological Surgery, The George Washington University, Foggy Bottom South Pavilion, 22nd Street, NW, 7th Floor, Washington, DC, 20037, United States.

PMID: 32116185
DOI: 10.2174/1381612826666200302105715

Abstract

Background: Studies from the past few years revealed the importance of Cold Atmospheric Plasma (CAP) on various kinds of diseases, including brain cancers or glioblastoma (GBM), and hence coined a new term 'Plasma Medicine' in the modern world for promising therapeutic approaches. Here, we focus on the efficacy of CAP and its liquid derivatives on direct interactions or with specific nanoparticles to show pivotal roles in brain cancer treatment.

Method: In the present review study, the authors studied several articles over the past decades published on the types of CAP and its effects on different brain cancers and therapy.

Results: A growing body of evidence indicates that CAP and its derivatives like Plasma Activated Media/ Water (PAM/PAW) are introduced in different kinds of GBM. Recent studies proposed that CAP plays a remarkable role in GBM treatment. To increase the efficacy of CAP, various nanoparticles of different origins got specific attention in recent times. In this review, different strategies to treat brain cancers, including nanoparticles, are discussed as enhancers of CAP induced targeted nanotherapeutic approach.

Conclusion: CAP treatment and its synergistic effects with different nanoparticles hold great promise for clinical applications in early diagnosis and treatment of GBM treatment. However, results obtained from previous studies were still in the preliminary phase, and there must be a concern over the use of optimal methods for a dosage of CAP and nanoparticles for complete cure of GBM.

Keywords: Cold Atmospheric Plasma (CAP); Plasma Activated Media/ Water (PAM/PAW); free radicals; glioblastoma; nanoparticles; plasma medicine..

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review

MeSH terms

Brain Neoplasms* / drug therapy
Glioblastoma* / drug therapy
Humans
Nanoparticles*
Plasma
Plasma Gases*

Substances

Plasma Gases