Preparation of dummy molecularly imprinted polymers based on dextran-modified magnetic nanoparticles Fe3O4 for the selective detection of acrylamide in potato chips

Can Zhang; Xiaoman Shi; Fangfang Yu; Ying Quan

doi:10.1016/j.foodchem.2020.126431

Preparation of dummy molecularly imprinted polymers based on dextran-modified magnetic nanoparticles Fe₃O₄ for the selective detection of acrylamide in potato chips

Food Chem. 2020 Jul 1:317:126431. doi: 10.1016/j.foodchem.2020.126431. Epub 2020 Feb 19.

Authors

Can Zhang¹, Xiaoman Shi², Fangfang Yu², Ying Quan³

Affiliations

¹ Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Technology and Business University (BTBU), PR China; School of Food & Biological Engineering, Jiangsu University, Zhenjiang 212013, PR China. Electronic address: zhangcan@mail.ujs.edu.cn.
² School of Food & Biological Engineering, Jiangsu University, Zhenjiang 212013, PR China.
³ School of Biotechnology and Food Engineering, Changshu Institute of Technology, Changshu, Jiangsu 215500, PR China.

PMID: 32109657
DOI: 10.1016/j.foodchem.2020.126431

Abstract

Novel dummy magnetic molecularly imprinted polymers (dex-MMIPs) were prepared for highly selective recognition and fast enrichment of acrylamide (AA) in potato chips. Propionamide (PA) was used as dummy template molecule and the Fe₃O₄ nanoparticles modified with carboxymethyl dextran were developed as supports. Methacrylic acid (MAA) and ethyleneglycoldimethacrylate (EGDMA) were chosen as the functional monomer and cross-linker, respectively. Fourier transform infrared (FTIR) spectroscopy, thermogravimetric analysis (TGA), and transmission electron microscopy (TEM) were used to characterize the synthesized dex-MMIPs. The adsorption of dex-MMIPs reached equilibrium within 20 min, and the maximum adsorption quantity (Q_m) was 19.28 mg/g with the dissociation constant (K_d) of 35.7 mg/L. Moreover excellent recognition toward acrylamide was achieved compared to analogs, such as N, N'-methylenebisacrylamide (MBA) and nicotinamide (VPP). The satisfactory recoveries of 83.9-96.8% were achieved for selective separation and enrichment of AA in spiked potato chips by dex-MMIPs.

Keywords: Acrylamide; Dextran; Dummy magnetic molecularly imprinted polymers; Fe(3)O(4) nanoparticles; Propionamide.

MeSH terms

Acrylamide / analysis*
Adsorption
Chromatography, High Pressure Liquid
Cooking
Dextrans / chemistry
Food Analysis / methods*
Food Contamination / analysis
Magnetics
Magnetite Nanoparticles / chemistry*
Methacrylates / chemistry
Microscopy, Electron, Transmission
Molecular Imprinting / methods*
Niacinamide / analysis
Polymers / chemistry*
Solanum tuberosum*
Spectroscopy, Fourier Transform Infrared
Thermogravimetry

Substances

Dextrans
Magnetite Nanoparticles
Methacrylates
Polymers
methacrylic acid
Acrylamide
Niacinamide
ethylene dimethacrylate
carboxymethyl dextran