The appliances and prospects of aurum nanomaterials in biodiagnostics, imaging, drug delivery and combination therapy

Dan Yang; Feiyang Deng; Dechun Liu; Bo He; Bing He; Xing Tang; Qiang Zhang

doi:10.1016/j.ajps.2018.06.002

The appliances and prospects of aurum nanomaterials in biodiagnostics, imaging, drug delivery and combination therapy

Asian J Pharm Sci. 2019 Jul;14(4):349-364. doi: 10.1016/j.ajps.2018.06.002. Epub 2018 Sep 14.

Authors

Dan Yang¹, Feiyang Deng², Dechun Liu², Bo He², Bing He², Xing Tang¹, Qiang Zhang^{1

2

3}

Affiliations

¹ School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China.
² Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery Systems, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.
³ State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, China.

Abstract

Aurum nanomaterials (ANM), combining the features of nanotechnology and metal elements, have demonstrated enormous potential and aroused great attention on biomedical applications over the past few decades. Particularly, their advantages, such as controllable particle size, flexible surface modification, higher drug loading, good stability and biocompatibility, especially unique optical properties, promote the development of ANM in biomedical field. In this review, we will discuss the advanced preparation process of ANM and summarize their recent applications as well as their prospects in diagnosis and therapy. Besides, multi-functional ANM-based theranostic nanosystems will be introduced in details, including radiotherapy (RT), photothermal therapy (PTT), photodynamic therapy (PDT), immunotherapy (IT), and so on.

Keywords: Combination therapy; Drug delivery; Gold nanomaterials; Imaging and biodiagnostics; Immunotherapy; Photothermal therapy.

Publication types

Review