Nine-Year Analysis of Isolated Pathogens and Antibiotic Susceptibilities of Infectious Endophthalmitis from a Large Referral Eye Center in Southern China

Lixia Lin; Feng Mei; Jingyu Liao; Yao Yang; Fang Duan; Xiaofeng Lin

doi:10.2147/IDR.S235954

Nine-Year Analysis of Isolated Pathogens and Antibiotic Susceptibilities of Infectious Endophthalmitis from a Large Referral Eye Center in Southern China

Infect Drug Resist. 2020 Feb 13:13:493-500. doi: 10.2147/IDR.S235954. eCollection 2020.

Authors

Lixia Lin^#¹, Feng Mei^#¹, Jingyu Liao¹, Yao Yang¹, Fang Duan¹, Xiaofeng Lin¹

Affiliation

¹ Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-Sen University, Guangzhou, People's Republic of China.

^# Contributed equally.

Abstract

Purpose: To analyze the pathogen spectrum of isolated pathogens and antibiotic susceptibility trends of infectious endophthalmitis over 9 years from a large referral eye center in southern China.

Methods: Data from all inpatients who were clinically diagnosed with infectious endophthalmitis and underwent microbiological evaluation at the Zhongshan Ophthalmic Center from January 2010 to December 2018 were collected retrospectively and analyzed according to different clinical etiologies.

Results: A total of 816 cases were collected in the study. Open-globe injuries had caused 473 (57.97%) cases, 70 (8.58%) cases presented endophthalmitis after infectious keratitis, 156 (19.12%) cases were postoperative, and endogenous causes accounted for 117 (14.34%) cases. Among the 309 culture-positive cases, the predominant pathogen for both postoperative and posttraumatic endophthalmitis was gram-positive cocci (59.52% and 49.72%, respectively). Regarding keratitis-related endophthalmitis, the main pathogens were filamentous fungi (57.58%) and gram-negative bacilli (30.30%). The pathogens of endogenous endophthalmitis were almost evenly distributed among gram-positive cocci, gram-negative bacilli, and fungi. Eighty-five (10.42%) cases underwent evisceration/enucleation, including 42 cases secondary to keratitis-related endophthalmitis. The incidence of evisceration/enucleation was much higher in keratitis-related endophthalmitis than the total endophthalmitis population (χ² =123.61, P<0.001). Overall bacteria showed high susceptibility to fluoroquinolones (75.36-100.00%). Gram-positive cocci showed much higher sensitivity to cephalosporins compared to gram-negative bacilli (85.11-92.59% vs 25.42-35.72%). For the five first-line antibiotics analyzed for time trend of susceptibility, four exhibited a significant decrease of susceptibility from 2010-2014 to 2015-2018.

Conclusion: Between 2010 and 2018, posttraumatic endophthalmitis was the most common form of the treated endophthalmitis in Zhongshan Ophthalmic Center. The causative pathogens varied according to different clinical settings. Even though the overall antibiotic susceptibilities were fairly high, we observed a substantial decrease of susceptibility for most first-line antibiotics.

Keywords: antibiotic resistance; evisceration/enucleation; infectious endophthalmitis; pathogen spectrum; time trend.

Grants and funding

This study was supported by grants from the Fundamental Research Funds of the State Key Laboratory of Ophthalmology (30306020240020130 and 3030902113030), and grants from the National Natural Science Foundation of China (81974135, 81400381, and 81900851).