Adaptation to Hypoxia: A Chimera?

Int J Mol Sci. 2020 Feb 24;21(4):1527. doi: 10.3390/ijms21041527.

Abstract

"The Chimera was, according to Greek mythology, a monstrous fire-breathing hybrid creature of Lycia in Asia Minor, composed of the parts of more than one animal [...].

Keywords: Adaptation; adaptation; apoptosis; cardiovascular disease; chronic hypoxia; high altitude; hyperoxia; hypoxia antagonists; hypoxia mimetics; hypoxia-inducible factors; intermittent hypoxia; oxygen sensing; pulmonary dysfunction; tumor microenvironment.

Publication types

  • Editorial
  • Introductory Journal Article

MeSH terms

  • Adaptation, Physiological / physiology*
  • Altitude*
  • Animals
  • Autophagy / physiology
  • Cholesterol, LDL / metabolism
  • Humans
  • Hypoxia / physiopathology*
  • Intracellular Signaling Peptides and Proteins / metabolism
  • Lipoproteins, HDL / metabolism
  • Mitochondrial Proteins / metabolism

Substances

  • Cholesterol, LDL
  • HIGD1A protein, human
  • Intracellular Signaling Peptides and Proteins
  • Lipoproteins, HDL
  • Mitochondrial Proteins