The efficacy of non-small cell lung cancer (NSCLC) has been obviously improved recent years, while the survival of small cell lung cancer (SCLC) patients remains inferior for limit treatment options. The incidence of SCLC accounts for 15% of the overall incidence of lung cancer, and it is characterized with high malignancy, rapid growth, early widespread metastasis, making it very difficult to treat. With the approval of immunotherapy for a variety of solid tumors including NSCLC, as a relatively immunogenic cancer species, relevant clinical researchs on SCLC are also underway and have made certain progress. More importantly, due to the existence of tumor heterogeneity, exploring relevant markers that can predict the efficacy of SCLC is essential for accurate therapy. This review describes the latest advances in SCLC immunotherapy and biomarkers related to the efficacy of immunotherapy.
【中文题目：小细胞肺癌免疫治疗及预后相关标志物的研究进展】 【中文摘要：近年来，虽然非小细胞肺癌患者的治疗效果得到了明显的改善，但小细胞肺癌（small cell lung cancer, SCLC）患者仍因治疗选择有限而预后很差。SCLC发病率占肺癌总体发病率的15%，具有恶性程度高、生长迅速、易发生远处转移及复发的特点，治疗十分棘手。随着免疫治疗获批于非小细胞肺癌等多种实体瘤，作为免疫源性相对较强的癌种，SCLC的相关临床研究也在开展中，并已取得一定的进展。另一方面，由于肿瘤异质性的存在，探索能够预测SCLC疗效的相关标志物对患者精准治疗至关重要。本综述阐述了目前SCLC免疫治疗及与SCLC免疫治疗相关生物标志物研究的最新进展。】 【中文关键词：肺肿瘤；免疫治疗；生物标志物】.
Keywords: Immunotherapy; Lung neoplsma; Predictive marker.