[Sleep-disordered breathing as a consequence of vagus nerve stimulation]

Rev Neurol. 2020 Mar 1;70(5):179-182. doi: 10.33588/rn.7005.2019332.
[Article in Spanish]

Abstract

Introduction: Vagus nerve stimulation (VNS) is indicated in cases of refractory epilepsy. Its side effects are frequently minor, however, breathing disturbances during sleep have been previously reported.

Case reports: Our three cases are representative of sleep-disordered breathing that occurred as a consequence of VNS activity in patients with refractory epilepsy. Sleep apnoea was observed in two patients and stridor in one patient.

Conclusions: Given the high prevalence of sleep apnoea-hypopnoea syndrome in patients with refractory epilepsy, implantation of VNS should be ideally preceded by an assessment of the breathing during sleep. Furthermore, sleep-disordered breathing should be considered as a rare complication of VNS, and sleep apnoea should be investigated alongside data regarding VNS firing.

Title: Alteraciones respiratorias durante el sueño a consecuencia de la estimulación del nervio vago.

Introducción. La estimulación del nervio vago (ENV) es una terapia utilizada en casos de epilepsia refractaria. Sus efectos secundarios son, con frecuencia, leves; sin embargo, se han descrito previamente alteraciones respiratorias durante el sueño. Casos clínicos. Los tres casos incluidos son representativos de alteraciones respiratorias durante el sueño (apnea del sueño y estridor) que surgen a consecuencia de la actividad de la ENV. Conclusiones. Dada la elevada prevalencia del síndrome de apnea/hipopnea durante el sueño en pacientes con epilepsia refractaria, debería estudiarse su posible preexistencia en candidatos a ENV y considerarse su potencial aparición como consecuencia de la ENV en el seguimiento de pacientes con ENV activa.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Anticonvulsants / therapeutic use
  • Drug Resistant Epilepsy / drug therapy
  • Drug Resistant Epilepsy / therapy
  • Electrocardiography
  • Electroencephalography
  • Electromyography
  • Female
  • Humans
  • Male
  • Middle Aged
  • Positive-Pressure Respiration
  • Respiratory Sounds / etiology
  • Respiratory Sounds / physiopathology
  • Sleep Apnea Syndromes / etiology*
  • Sleep Apnea Syndromes / therapy
  • Sleep Apnea, Obstructive / etiology
  • Sleep Apnea, Obstructive / therapy
  • Vagus Nerve Stimulation / adverse effects*

Substances

  • Anticonvulsants