Congenital Cytomegalovirus Infection Presenting with Hyperbilirubinemia and Splenomegaly in a Term Infant with Trisomy 21

Kate Wilson; Lindsay Ellsworth; Megan H Pesch

doi:10.1155/2020/2534629

Congenital Cytomegalovirus Infection Presenting with Hyperbilirubinemia and Splenomegaly in a Term Infant with Trisomy 21

Case Rep Pediatr. 2020 Feb 12:2020:2534629. doi: 10.1155/2020/2534629. eCollection 2020.

Authors

Kate Wilson¹, Lindsay Ellsworth¹, Megan H Pesch^{2

3}

Affiliations

¹ Division of Neonatal Perinatal Medicine, Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI, USA.
² Division of Developmental and Behavioral Pediatrics, University of Michigan Medical School, Ann Arbor, MI, USA.
³ Center for Human Growth and Development, University of Michigan, Ann Arbor, MI, USA.

Abstract

Congenital cytomegalovirus infection (cCMV) is very common, yet the presentation can be varied, making the diagnosis challenging. However, early diagnosis for treatment with medication in symptomatic cases within the first month of life is critical. Hyperbilirubinemia and splenomegaly are less common manifestations at birth and may be overlooked in the setting of other symptoms, especially in a critically ill neonate. We present a case of a term infant with trisomy 21 who presented with isolated hyperbilirubinemia and splenomegaly and was later diagnosed with congenital CMV.

Publication types

Case Reports