Impact of Intraoperative Ocular Lubricants on Corneal Debridement Rate During Vitreoretinal Surgery

Michael L Mathison; Albert S Li; Yicheng K Bao; Andrew Jw Huang; Rithwick Rajagopal

doi:10.2147/OPTH.S234149

Impact of Intraoperative Ocular Lubricants on Corneal Debridement Rate During Vitreoretinal Surgery

Clin Ophthalmol. 2020 Feb 4:14:347-352. doi: 10.2147/OPTH.S234149. eCollection 2020.

Authors

Michael L Mathison¹, Albert S Li¹, Yicheng K Bao², Andrew Jw Huang¹, Rithwick Rajagopal¹

Affiliations

¹ Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, Saint Louis, MO 63110, USA.
² Department of Medicine, University of Missouri - Kansas City School of Medicine, Kansas City, MO 64112, USA.

Abstract

Purpose: To compare surgical parameters among patients receiving Viscoat (sodium chondroitin sulfate 4%-sodium hyaluronate 3%) or Goniosol (hydroxypropyl methylcellulose 2.5%) as topical lubricants for retinal surgery.

Methods: This was a retrospective analysis of patients undergoing retinal surgery between March 2013 and March 2018 using Goniosol or Viscoat as adjuvants. Primary outcome measures were rate of corneal debridement and operative time between groups, compared using χ ² and t-tests, respectively.

Results: Compared to Viscoat (n=319), the Goniosol group (n=210) had more frequent intraoperative corneal debridement (21.4% vs 0, p<0.05) and longer surgical times (98 vs 78 minutes, p<0.05). Patients in the Viscoat group had higher rates of complex procedures (34.8% vs 26.7%, p<0.05), but were younger (50.7 vs 55.0 years, p<0.05) and more likely to be phakic (83.4% vs 70.5%, p<0.05).

Conclusion: These findings suggest potential advantages of using Viscoat over Goniosol for corneal lubrication to aid visualization during vitreoretinal surgery.

Keywords: corneal debridement; corneal edema; corneal epithelium; vitreoretinal surgery; Goniosol; Viscoat.

Grants and funding

NIH/NEI EY025269 (RR), NIH/NEI EY002687 (Washington University Depertment of Ophthalmology and Visual Sciences), NIH/NIDDK T32DK007120 (YKB), Career Development Award from Research to Prevent Blindness (RR), an Unrestricted Award from Research to Prevent Blindness (Washington University Department of Ophthalmology and Visual Sciences), Horncrest Foundation Support (RR), UMKC School of Medicine Sarah Morrison Research Award (YKB).