Chronic traumatic encephalopathy in a former Australian rules football player diagnosed with Alzheimer's disease

Alan J Pearce; Joanne Sy; Maggie Lee; Antony Harding; Rowena Mobbs; Jennifer Batchelor; Catherine M Suter; Michael E Buckland

doi:10.1186/s40478-020-0895-z

Chronic traumatic encephalopathy in a former Australian rules football player diagnosed with Alzheimer's disease

Acta Neuropathol Commun. 2020 Feb 26;8(1):23. doi: 10.1186/s40478-020-0895-z.

Authors

Alan J Pearce¹, Joanne Sy², Maggie Lee^{2

3}, Antony Harding^{2

3}, Rowena Mobbs^{3

4}, Jennifer Batchelor⁴, Catherine M Suter², Michael E Buckland^{5

6}

Affiliations

¹ College of Science, Health and Engineering, La Trobe University, Bundoora, VIC, 3086, Australia.
² Department of Neuropathology, Royal Prince Alfred Hospital, Camperdown, NSW, 2050, Australia.
³ Brain & Mind Centre, University of Sydney, Camperdown, NSW, 2006, Australia.
⁴ Macquarie University, Macquarie Park, NSW, 2109, Australia.
⁵ Department of Neuropathology, Royal Prince Alfred Hospital, Camperdown, NSW, 2050, Australia. michael.buckland@sydney.edu.au.
⁶ Brain & Mind Centre, University of Sydney, Camperdown, NSW, 2006, Australia. michael.buckland@sydney.edu.au.

No abstract available

Keywords: Australian football league; Chronic traumatic encephalopathy; Concussion; Dementia; Neurodegeneration; Occupational health; Public health; Repetitive head injury; Tau; Traumatic brain injury.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Aged, 80 and over
Aggression
Alzheimer Disease* / complications
Alzheimer Disease* / metabolism
Alzheimer Disease* / pathology
Astrocytes* / metabolism
Astrocytes* / pathology
Atrophy
Australia
Brain* / metabolism
Brain* / pathology
Cerebral Small Vessel Diseases* / complications
Cerebral Small Vessel Diseases* / pathology
Chronic Traumatic Encephalopathy* / complications
Chronic Traumatic Encephalopathy* / metabolism
Chronic Traumatic Encephalopathy* / pathology
DNA-Binding Proteins / metabolism
Depression
Frontal Lobe / metabolism
Frontal Lobe / pathology
Humans
Hydrocephalus / etiology
Hydrocephalus / pathology
Immunohistochemistry
Male
Memory Disorders / etiology
Neurofibrillary Tangles / metabolism
Neurofibrillary Tangles / pathology
Neurons* / metabolism
Neurons* / pathology
Parkinsonian Disorders / etiology
REM Sleep Behavior Disorder / etiology
Sports*
Temporal Lobe / metabolism
Temporal Lobe / pathology
tau Proteins* / metabolism

Substances

DNA-Binding Proteins
MAPT protein, human
TARDBP protein, human
tau Proteins