The growing evidence for targeting P-glycoprotein in lysosomes to overcome resistance

Sven Marcel Stefan; Patric J Jansson; Danuta S Kalinowski; Rukhsana Anjum; Mahendiran Dharmasivam; Des R Richardson

doi:10.4155/fmc-2019-0350

The growing evidence for targeting P-glycoprotein in lysosomes to overcome resistance

Future Med Chem. 2020 Mar;12(6):473-477. doi: 10.4155/fmc-2019-0350. Epub 2020 Feb 26.

Authors

Sven Marcel Stefan¹, Patric J Jansson¹, Danuta S Kalinowski¹, Rukhsana Anjum¹, Mahendiran Dharmasivam¹, Des R Richardson¹

Affiliation

¹ Molecular Pharmacology & Pathology Program, Department of Pathology & Bosch Institute, The University of Sydney, Sydney, NSW 2006, Australia.

PMID: 32098489
DOI: 10.4155/fmc-2019-0350

No abstract available

Keywords: ABCB1 lysosomes; P-gp; P-gp endocytosis; lysosomal P-gp activity; lysosomal membrane permeabilization; redox-active (-cycling) thiosemicarbazone complexes; thiosemicarbazone; thiosemicarbazone ionization.

Publication types

Editorial
Research Support, Non-U.S. Gov't
Review

MeSH terms

ATP Binding Cassette Transporter, Subfamily B, Member 1 / antagonists & inhibitors*
ATP Binding Cassette Transporter, Subfamily B, Member 1 / metabolism
Animals
Antineoplastic Agents / pharmacology*
Drug Resistance, Multiple / drug effects*
Drug Resistance, Neoplasm / drug effects*
Humans
Lysosomes / chemistry
Lysosomes / metabolism
Thiosemicarbazones / pharmacology*

Substances

ATP Binding Cassette Transporter, Subfamily B, Member 1
Antineoplastic Agents
Thiosemicarbazones