Lipid membranes supported by planar porous substrates

Yanping Sun; Xianghuan Zang; Yongjun Sun; Long Wang; Zibin Gao

doi:10.1016/j.chemphyslip.2020.104893

Lipid membranes supported by planar porous substrates

Chem Phys Lipids. 2020 May:228:104893. doi: 10.1016/j.chemphyslip.2020.104893. Epub 2020 Feb 22.

Authors

Yanping Sun¹, Xianghuan Zang², Yongjun Sun³, Long Wang⁴, Zibin Gao⁵

Affiliations

¹ Department of Pharmacy, Hebei University of Science and Technology, Shijiazhuang, 050018, China; State Key Laboratory Breeding Base - Hebei Province Key Laboratory of Molecular Chemistry for Drugs, Hebei University of Science and Technology, Shijiazhuang, 050018, China; Hebei Research Center of Pharmaceutical and Chemical Engineering, Hebei University of Science and Technology, Shijiazhuang, 050018, China.
² Department of Pharmacy, Hebei University of Science and Technology, Shijiazhuang, 050018, China.
³ Department of Pharmacy, Hebei University of Science and Technology, Shijiazhuang, 050018, China; Hebei Research Center of Pharmaceutical and Chemical Engineering, Hebei University of Science and Technology, Shijiazhuang, 050018, China.
⁴ State Key Laboratory Breeding Base - Hebei Province Key Laboratory of Molecular Chemistry for Drugs, Hebei University of Science and Technology, Shijiazhuang, 050018, China; Department of Family and Consumer Sciences, California State University, Long Beach, CA, 90840, USA. Electronic address: long.wang@csulb.edu.
⁵ Department of Pharmacy, Hebei University of Science and Technology, Shijiazhuang, 050018, China; State Key Laboratory Breeding Base - Hebei Province Key Laboratory of Molecular Chemistry for Drugs, Hebei University of Science and Technology, Shijiazhuang, 050018, China; Hebei Research Center of Pharmaceutical and Chemical Engineering, Hebei University of Science and Technology, Shijiazhuang, 050018, China. Electronic address: syswz320@163.com.

PMID: 32097619
DOI: 10.1016/j.chemphyslip.2020.104893

Abstract

Biological membranes play key roles in cell life, but their intrinsic complexity motivated the study and development of artificial lipid membranes with the primary aim to reconstitute and understand the natural functions in vitro. Porous-supported lipid membrane (pSLM) has emerged as a flexible platform for studying the surface chemistry of the cell due to their high stability and fluidity, and their ability to study the transmembrane process of the molecules. In this review, the pSLM, for the first time, to our knowledge, was divided into three types according to the way of the porous materials support the lipid membrane, containing the lipid membrane on the pores of the porous materials, the lipid membrane on both sides of the porous materials, the lipid membrane in the pores of the porous materials. All of these pSLMs were systematically elaborated from several aspects, including the substrates, formation, and characterization. Meanwhile, the advantages and disadvantages of each model membranes were summarized. Finally, suggestions for selecting appropriate pSLM and future directions in this area are discussed.

Keywords: Applications; Model membranes; Porous materials; Porous-supported lipid membrane.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Hydrophobic and Hydrophilic Interactions
Lipid Bilayers / chemistry*
Membranes, Artificial
Porosity
Surface Properties

Substances

Lipid Bilayers
Membranes, Artificial