DIMERBOW: exploring possible GPCR dimer interfaces

Adrián García-Recio; Gemma Navarro; Rafael Franco; Mireia Olivella; Ramon Guixà-González; Arnau Cordomí

doi:10.1093/bioinformatics/btaa117

DIMERBOW: exploring possible GPCR dimer interfaces

Bioinformatics. 2020 May 1;36(10):3271-3272. doi: 10.1093/bioinformatics/btaa117.

Authors

Adrián García-Recio¹, Gemma Navarro^{2

3}, Rafael Franco^{3

4}, Mireia Olivella⁵, Ramon Guixà-González^{1

6

7}, Arnau Cordomí¹

Affiliations

¹ Laboratori de Medicina Computacional, Unitat de Bioestadistica, Facultat de Medicina, Universitat Autònoma de Barcelona, Bellaterra 08193, Spain.
² Department of Biochemistry and Physiology, Universitat de Barcelona, Barcelona, Spain.
³ CiberNed, Centro De Investigacion En Red, Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid, Spain.
⁴ Department of Biochemistry and Molecular Biomedicine, Faculty of Biology, Universitat de Barcelona, Barcelona, Spain.
⁵ Bioinformatics and Medical Statistics Group, Biosciences Department, University of Vic-Central University of Catalonia, Barcelona, Spain.
⁶ Laboratory of Biomolecular Research.
⁷ Condensed Matter Theory Group, Paul Scherrer Institute (PSI), Villigen PSI 5232, Switzerland.

PMID: 32096817
DOI: 10.1093/bioinformatics/btaa117

Abstract

Motivation: G protein-coupled receptors (GPCRs) can form homo-, heterodimers and larger order oligomers that exert different functions than monomers. The pharmacological potential of such complexes is hampered by the limited information available on the type of complex formed and its quaternary structure. Several GPCR structures in the Protein Data Bank display crystallographic interfaces potentially compatible with physiological interactions.

Results: Here, we present DIMERBOW, a database and web application aimed to visually browse the complete repertoire of potential GPCR dimers present in solved structures. The tool is suited to help finding the best possible structural template to model GPCR homomers.

Availability and implementation: DIMERBOW is available at http://lmc.uab.es/dimerbow/.

Supplementary information: Supplementary data are available at Bioinformatics online.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Databases, Protein
Macromolecular Substances
Receptors, G-Protein-Coupled*

Substances

Macromolecular Substances
Receptors, G-Protein-Coupled