Decellularized extracellular matrix (dECM) has been widely used as a scaffold for regenerative medicine due to its high biomimetic and excellent biocompatibility. As a functional polymer material with high water content and controlled fluidity, hydrogel is very promising for some minimally invasive surgery in clinical practice. In recent years, with the rapid development of hydrogel theory and technology, dECM hydrogel has gradually become a research hotspot in the field of regenerative medicine. In this paper, the related researches in recent years are reviewed regarding the preparation of dECM hydrogel and its preclinical application. The future clinical use is also prospected.
脱细胞基质（dECM）由于其高仿生性和优异的生物相容性，已被广泛用作再生医学的支架材料。水凝胶（hydrogel）作为一种高含水量、可控流动性的功能高分子材料，非常适合用于临床中的部分微创手术。近年来，随着水凝胶理论和技术的快速发展，dECM 水凝胶逐渐成为再生医学领域的研究热点。本文从 dECM 水凝胶的制备及其临床前应用两个方面对近年来的相关研究进行综述，并展望其未来的临床前景。.
Keywords: decellularized extracellular matrix; hydrogel; regenerative medicine; tissue engineering.