Primary Angle Closure Glaucoma-associated Genetic Polymorphisms in Northeast Iran

Ali Yousefian; Saeed Shokoohi-Rad; Mohammad Reza Abbaszadegan; Dorsa Morshedi Rad; Selma Zargari; Saman Milanizadeh; Negar Morovatdar; Ramin Daneshvar

doi:10.18502/jovr.v15i1.5942

Primary Angle Closure Glaucoma-associated Genetic Polymorphisms in Northeast Iran

J Ophthalmic Vis Res. 2020 Feb 2;15(1):45-52. doi: 10.18502/jovr.v15i1.5942. eCollection 2020 Jan-Mar.

Authors

Ali Yousefian¹, Saeed Shokoohi-Rad¹, Mohammad Reza Abbaszadegan², Dorsa Morshedi Rad³, Selma Zargari², Saman Milanizadeh², Negar Morovatdar⁴, Ramin Daneshvar¹

Affiliations

¹ Eye Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
² Medical Genetics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
³ Immunology Research Center, Avicenna Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
⁴ Clinical Research Unit, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Abstract

Purpose: To evaluate the association of five different polymorphisms from a genome-wide-associated study with susceptibility to glaucoma in the northeast Iranian population.

Methods: Hundred and thirty patients with primary angle closure glaucoma (PACG) and 130 healthy controls were genotyped for the polymorphic regions with the aid of tetra-amplification refractory mutation system-polymerase chain reaction. The association of these variants with the disease susceptibility was measured statistically with the logistic regression method.

Results: Hundred and thirty patients with PACG (53 males, 77 females) with a mean age of 64.5 $\pm$ 6.2 years and 130 healthy control subjects (51 males, 79 females) with a mean age of 64.0 $\pm$ 5.7 years were selected for evaluation. There was a significant association between rs3816415 (P = 0.005), rs736893 (P $<$ 0.001), rs7494379 (P $<$ 0.001), and rs1258267 (P = 0.02) with PACG susceptibility. This association could not be shown for rs3739821.

Conclusion: It was revealed that studied variants in GLIS3, EPDR1, FERMT2, and CHAT genes can contribute to the incidence of PACG. Additional studies in other populations are needed to evaluate DPM2-FAM102A.

Keywords: Primary Angle Closure Glaucoma; rs1258267; rs3816415; rs736893; rs7494379; Polymorphism.

Publication types

Review