Genetic analysis of Yunnan sudden unexplained death by whole genome sequencing in Southwest of China

Lan-Jiang Li; Yue-Bing Wang; Peng-Fei Qu; Lin Ma; Kai Liu; Lin Yang; Sheng-Jie Nie; Yan-Mei Xi; Peng-Lin Jia; Xue Tang; Zhong-Chun Sun; Wen-Li Huang; Yu-Hua Li; Yi Dong; Pu-Ping Lei

doi:10.1016/j.jflm.2020.101896

Genetic analysis of Yunnan sudden unexplained death by whole genome sequencing in Southwest of China

J Forensic Leg Med. 2020 Feb:70:101896. doi: 10.1016/j.jflm.2020.101896. Epub 2020 Jan 23.

Authors

Lan-Jiang Li¹, Yue-Bing Wang², Peng-Fei Qu³, Lin Ma⁴, Kai Liu⁵, Lin Yang⁶, Sheng-Jie Nie⁷, Yan-Mei Xi⁸, Peng-Lin Jia⁹, Xue Tang¹⁰, Zhong-Chun Sun¹¹, Wen-Li Huang¹², Yu-Hua Li¹³, Yi Dong¹⁴, Pu-Ping Lei¹⁵

Affiliations

¹ Department of Forensic Medicine, Kunming Medical University, Yunnan Province, China. Electronic address: 445601505@qq.com.
² Yunnan Institute of Endemic Disease Control and Prevention, Yunnan Province, China. Electronic address: yiedcwyb@163.com.
³ Department of Forensic Medicine, Kunming Medical University, Yunnan Province, China. Electronic address: 1589671940@qq.com.
⁴ Yunnan Institute of Endemic Disease Control and Prevention, Yunnan Province, China. Electronic address: malian20@163.com.
⁵ Department of Forensic Medicine, Kunming Medical University, Yunnan Province, China. Electronic address: 532583930@qq.com.
⁶ Yunnan Institute of Endemic Disease Control and Prevention, Yunnan Province, China. Electronic address: 1277045054@qq.com.
⁷ Department of Forensic Medicine, Kunming Medical University, Yunnan Province, China. Electronic address: nieshengjie@126.com.
⁸ Yunnan Institute of Endemic Disease Control and Prevention, Yunnan Province, China. Electronic address: zizixi9823@qq.com.
⁹ Department of Forensic Medicine, Kunming Medical University, Yunnan Province, China. Electronic address: 154968795@qq.com.
¹⁰ Yunnan Institute of Endemic Disease Control and Prevention, Yunnan Province, China. Electronic address: 67633346@qq.com.
¹¹ Department of Forensic Medicine, Kunming Medical University, Yunnan Province, China. Electronic address: sunzhongchun315@163.com.
¹² Yunnan Institute of Endemic Disease Control and Prevention, Yunnan Province, China. Electronic address: hwenli63@163.com.
¹³ Department of Forensic Medicine, Kunming Medical University, Yunnan Province, China. Electronic address: 1051680478@qq.com.
¹⁴ Yunnan Institute of Endemic Disease Control and Prevention, Yunnan Province, China. Electronic address: 243828212@qq.com.
¹⁵ Department of Forensic Medicine, Kunming Medical University, Yunnan Province, China. Electronic address: puping.jacky@qq.com.

PMID: 32090967
DOI: 10.1016/j.jflm.2020.101896

No abstract available

Keywords: Negative autopsy; Pathogenic variants; Sudden unexplained death; Whole genome sequencing.

MeSH terms

3-Hydroxyacyl CoA Dehydrogenases / genetics
A Kinase Anchor Proteins / genetics
Adult
Amino Acid Substitution / genetics
Child, Preschool
China
Cytoskeletal Proteins / genetics
Death, Sudden, Cardiac / etiology*
Female
Heterozygote
Humans
Male
Middle Aged
Nuclear Pore Complex Proteins / genetics
Polymorphism, Single Nucleotide
Sequence Analysis, DNA
Whole Genome Sequencing*

Substances

A Kinase Anchor Proteins
AKAP9 protein, human
Cytoskeletal Proteins
NUP155 protein, human
Nuclear Pore Complex Proteins
3-Hydroxyacyl CoA Dehydrogenases