Abstract
Herein, we report the chemoenzymatic synthesis of a heterodimeric (-)-rugulosin B, homodimeric (-)-rugulosin C, and several rugulin analogues in three to four steps starting from anthraquinones. This work supports dimerization between variously substituted putative monomeric intermediates during the biosynthesis of naturally occurring (+)-rugulosin B and C.
MeSH terms
-
Anthraquinones / chemical synthesis*
-
Anthraquinones / chemistry
-
Anthraquinones / metabolism
-
Biomimetics
-
Coordination Complexes / chemistry
-
Cycloaddition Reaction
-
Fungal Proteins / genetics
-
Fungal Proteins / metabolism
-
Lead / chemistry
-
Naphthoquinones / chemical synthesis
-
Naphthoquinones / chemistry*
-
Naphthoquinones / metabolism
-
Oxidation-Reduction
-
Oxidoreductases / genetics
-
Oxidoreductases / metabolism*
-
Talaromyces / enzymology
Substances
-
Anthraquinones
-
Coordination Complexes
-
Fungal Proteins
-
Naphthoquinones
-
rugulosin B
-
rugulosin C
-
Lead
-
rugulin
-
Oxidoreductases