Acetic Acid-Induced Ulcerative Colitis in Sprague Dawley Rats Is Suppressed by Hydroethanolic Extract of Cordia vignei Leaves through Reduced Serum Levels of TNF- α and IL-6

George Owusu; David D Obiri; George K Ainooson; Newman Osafo; Aaron O Antwi; Babatunde M Duduyemi; Charles Ansah

doi:10.1155/2020/8785497

Acetic Acid-Induced Ulcerative Colitis in Sprague Dawley Rats Is Suppressed by Hydroethanolic Extract of Cordia vignei Leaves through Reduced Serum Levels of TNF- α and IL-6

Int J Chronic Dis. 2020 Feb 6:2020:8785497. doi: 10.1155/2020/8785497. eCollection 2020.

Authors

George Owusu^{1

2}, David D Obiri¹, George K Ainooson¹, Newman Osafo¹, Aaron O Antwi¹, Babatunde M Duduyemi³, Charles Ansah¹

Affiliations

¹ Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, College of Health Sciences, Kwame Nkrumah University of Science and Technology (KNUST), Kumasi, Ghana.
² Department of Pharmacology, School of Medicine and Health Sciences, University for Development Studies, Tamale, Ghana.
³ Department of Pathology, School of Medical Sciences, Kwame Nkrumah University of Science and Technology (KNUST), Kumasi, Ghana.

Abstract

Background: Ulcerative colitis (UC) is a recurrent inflammatory bowel disease (IBD) that causes long-lasting inflammation on the innermost lining of the colon and rectum. Leaf decoctions of Cordia vignei have been used in traditional medicine either alone or in combination with other plant preparations to treat the disease.

Aim: In this study, we investigated the effect of hydroethanolic extract of Cordia vignei have been used in traditional medicine either alone or in combination with other plant preparations to treat the disease.

Method: Male Sprague Dawley rats received oral treatment of either saline (10 ml/kg), sulfasalazine (500 mg/kg), or CVE (30-300 mg/kg) daily for 7 days. On day 4, colitis was induced by a single intrarectal administration of 500 μl of acetic acid (4% v/v/.

Results: CVE significantly (P < 0.05) prevented colonic ulceration and reduced the inflammatory score. Serum levels of TNF-α and IL-6 were significantly reduced. Depletion of superoxide dismutase (SOD) and catalase (CAT) activities by acetic acid was significantly inhibited while lipid peroxidation indexed as malondialdehyde (MDA) level in the colon was reduced. However, loss of body weight was not significantly affected by treatment with CVE.

Conclusion: This data suggest that CVE has a potential antiulcerative effect.