Transcriptome-wide and differential expression network analyses of childhood asthma in nasal epithelium

J Allergy Clin Immunol. 2020 Sep;146(3):671-675. doi: 10.1016/j.jaci.2020.02.005. Epub 2020 Feb 20.

Abstract

In a transcription-wide association study of nasal epithelium, we identify novel and previously reported susceptibility genes for atopic asthma in children and show that gene co-expression networks differ markedly between children with and without atopic asthma.

Publication types

  • Letter
  • Research Support, N.I.H., Extramural

MeSH terms

  • Adolescent
  • Adult
  • Asthma / blood
  • Asthma / epidemiology
  • Asthma / genetics*
  • Case-Control Studies
  • Child
  • Female
  • Gene Expression Profiling
  • Humans
  • Immunoglobulin E / blood
  • Male
  • Nasal Mucosa / metabolism*
  • Transcriptome
  • Young Adult

Substances

  • Immunoglobulin E