Glycolipid-mediated basophil activation in alpha-gal allergy

Onyinye I Iweala; Shailesh K Choudhary; Claire T Addison; Cole J Batty; Camille M Kapita; Claire Amelio; Alexander J Schuyler; Shenglou Deng; Eric M Bachelder; Kristy M Ainslie; Paul B Savage; Patrick J Brennan; Scott P Commins

doi:10.1016/j.jaci.2020.02.006

Glycolipid-mediated basophil activation in alpha-gal allergy

J Allergy Clin Immunol. 2020 Aug;146(2):450-452. doi: 10.1016/j.jaci.2020.02.006. Epub 2020 Feb 20.

Affiliations

¹ Department of Medicine, Thurston Arthritis Research Center, Division of Rheumatology, Allergy, and Immunology, Chapel Hill, NC; Department of Pediatrics, University of North Carolina Food Allergy Initiative, Division of Allergy, Immunology and Rheumatology, Chapel Hill, NC. Electronic address: onyinye.iweala@med.unc.edu.
² Department of Medicine, Thurston Arthritis Research Center, Division of Rheumatology, Allergy, and Immunology, Chapel Hill, NC.
³ the Eshelman School of Pharmacy, Division of Pharmacoengineering and Molecular Pharmaceutics, The University of North Carolina at Chapel Hill, Chapel Hill, NC.
⁴ the Division of Allergy & Clinical Immunology, University of Virginia, Charlottesville, Va.
⁵ the Department of Chemistry and Biochemistry, Brigham Young University, Provo, Utah.
⁶ the Department of Medicine, Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass.
⁷ Department of Medicine, Thurston Arthritis Research Center, Division of Rheumatology, Allergy, and Immunology, Chapel Hill, NC; Department of Pediatrics, University of North Carolina Food Allergy Initiative, Division of Allergy, Immunology and Rheumatology, Chapel Hill, NC.

Abstract

Alpha-gal-containing glycolipids activate basophils sensitized with plasma from alpha-gal allergic subjects in an IgE-dependent manner suggesting a role for glycolipid in the effector phase of IgE-mediated food allergy.

Publication types

Letter
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Allergens / immunology
Antigens, CD1d / metabolism
Basophil Degranulation Test
Basophils / immunology*
Cell Degranulation
Cells, Cultured
Food Hypersensitivity / immunology*
Glycolipids / immunology*
Humans
Immunoglobulin E / metabolism
Red Meat
alpha-Galactosidase / immunology

Substances

Allergens
Antigens, CD1d
Glycolipids
Immunoglobulin E
GLA protein, human
alpha-Galactosidase

Supplementary concepts

red meat allergy

Glycolipid-mediated basophil activation in alpha-gal allergy

Authors

Affiliations

Abstract

Publication types

MeSH terms

Substances

Supplementary concepts

Grants and funding