The systemic role of SIRT1 in exercise mediated adaptation

Zsolt Radak; Katsuhiko Suzuki; Aniko Posa; Zita Petrovszky; Erika Koltai; Istvan Boldogh

doi:10.1016/j.redox.2020.101467

The systemic role of SIRT1 in exercise mediated adaptation

Redox Biol. 2020 Aug:35:101467. doi: 10.1016/j.redox.2020.101467. Epub 2020 Feb 14.

Authors

Zsolt Radak¹, Katsuhiko Suzuki², Aniko Posa³, Zita Petrovszky³, Erika Koltai⁴, Istvan Boldogh⁵

Affiliations

¹ Research Institute of Sport Science, University of Physical Education, Budapest, Hungary; Faculty of Sport Sciences, Waseda University, Saitama, 359-1192, Japan; University of Szeged, Szeged, Hungary. Electronic address: radak@tf.hu.
² Faculty of Sport Sciences, Waseda University, Saitama, 359-1192, Japan.
³ University of Szeged, Szeged, Hungary.
⁴ Research Institute of Sport Science, University of Physical Education, Budapest, Hungary.
⁵ Department of Microbiology and Immunology, University of Texas Medical Branch at Galveston, Galveston, TX, 77555, USA.

Abstract

Cellular energy demands are readily changed during physical exercise resulting in adaptive responses by signaling proteins of metabolic processes, including the NAD⁺ dependent lysine deacetylase SIRT1. Regular exercise results in systemic adaptation that restores the level of SIRT1 in the kidney, liver, and brain in patients with neurodegenerative diseases, and thereby normalizes cellular metabolic processes to attenuate the severity of these diseases. In skeletal muscle, over-expression of SIRT1 results in enhanced numbers of myonuclei improves the repair process after injury and is actively involved in muscle hypertrophy by up-regulating anabolic and downregulating catabolic processes. The present review discusses the different views of SIRT1 dependent deacetylation of PGC-α.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Exercise*
Humans
Muscle, Skeletal
Sirtuin 1* / genetics

Substances

SIRT1 protein, human
Sirtuin 1