A Review on Sources and Pharmacological Aspects of Sakuranetin

Nutrients. 2020 Feb 18;12(2):513. doi: 10.3390/nu12020513.

Abstract

Sakuranetin belongs to the group of methoxylated flavanones. It is widely distributed in Polyomnia fruticosa and rice, where it acts as a phytoalexin. Other natural sources of this compound are, among others, grass trees, shrubs, flowering plants, cheery, and some herbal drugs, where it has been found in the form of glycosides (mainly sakuranin). Sakuranetin has antiproliferative activity against human cell lines typical for B16BL6 melanoma, esophageal squamous cell carcinoma (ESCC) and colon cancer (Colo 320). Moreover, sakuranetin shows antiviral activity towards human rhinovirus 3 and influenza B virus and was reported to have antioxidant, antimicrobial, antiinflammatory, antiparasitic, antimutagenic, and antiallergic properties. The aim of this review is to present the current status of knowledge of pro-health properties of sakuranetin.

Keywords: anticancer and antimicrobial activity; metoxhoxylated flavanones; sakuranetin.

Publication types

  • Review

MeSH terms

  • Anti-Allergic Agents
  • Anti-Infective Agents*
  • Anti-Inflammatory Agents
  • Antioxidants*
  • Antiparasitic Agents
  • Antiviral Agents*
  • Cell Proliferation / drug effects*
  • Colonic Neoplasms / pathology*
  • Esophageal Neoplasms / pathology*
  • Esophageal Squamous Cell Carcinoma / pathology*
  • Flavonoids / chemistry
  • Flavonoids / isolation & purification
  • Flavonoids / pharmacology*
  • Glycosides
  • Humans
  • Melanoma / pathology*
  • Oryza / chemistry
  • Phytoalexins
  • Phytotherapy
  • Prunus / chemistry*
  • Sesquiterpenes
  • Tumor Cells, Cultured

Substances

  • Anti-Allergic Agents
  • Anti-Infective Agents
  • Anti-Inflammatory Agents
  • Antioxidants
  • Antiparasitic Agents
  • Antiviral Agents
  • Flavonoids
  • Glycosides
  • Sesquiterpenes
  • sakuranetin
  • Phytoalexins