The Nucleotide-Free State of the Cannabinoid CB2/Gi Complex

Diane L Lynch; Dow P Hurst; Patricia H Reggio

doi:10.1016/j.cell.2020.01.034

The Nucleotide-Free State of the Cannabinoid CB2/Gi Complex

Cell. 2020 Feb 20;180(4):603-604. doi: 10.1016/j.cell.2020.01.034.

Authors

Diane L Lynch¹, Dow P Hurst¹, Patricia H Reggio²

Affiliations

¹ Department of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, NC 27412, USA.
² Department of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, NC 27412, USA. Electronic address: phreggio@uncg.edu.

PMID: 32084338
DOI: 10.1016/j.cell.2020.01.034

Abstract

In this issue of Cell, two papers report agonist-bound cryo-EM structures of the cannabinoid receptor, CB2, in complex with Gi. Importantly, beyond providing information that could help distinguish CB2 ligand binding from CB1, these structures support the existence of a nucleotide-free state during G-protein signaling.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Cannabinoids*
Cryoelectron Microscopy
GTP-Binding Proteins
Humans
Receptor, Cannabinoid, CB2*
Signal Transduction

Substances

Cannabinoids
Receptor, Cannabinoid, CB2
GTP-Binding Proteins

Grants and funding

K05 DA021358/DA/NIDA NIH HHS/United States